Programme
Wednesday, 11 June
| 12:30-15:00 |
Registration |
| 15:00-15:15 |
Welcome Address Gennaro Ciliberto and Alessandro Quattrone |
| Session I |
Molecular trafficking Chair: Gennaro Ciliberto (Naples) |
| 15:15-16:00 |
Marino Zerial (Dresden, Germany) Multi-scale analysis of cell and tissue organization |
| 16:00-16:20 |
Coffee Break |
| 16:20-16:35 |
Poster talk: Giovanni Sorrentino (Trieste) Metabolic control of YAP and TAZ by the mevalonate pathway |
| 16:35-17:15 |
Maria Carmo-Fonseca (Lisbon, Portugal) The timing of pre-mRNA splicing visualized in real-time |
| 17:15-17:30 |
Poster talk: Thomas Vaccari (Milan) Multiple functions of the SNARE protein Snap29 in membrane trafficking during epithelial formation in Drosophila |
| 17:30-18:10 |
Roberto Sitia (Milan) Integrating protein transport, quality control and signaling at the ER Golgi interface |
| 18:10-20:00 |
Poster Session I (odd numbers) & Wine and cheese |
Thursday, 12 June
| Session II |
Chromatin plasticity, transcription and translational control Chairs: Valeria Poli (Turin), Davide Corona (Palermo) |
| 8:30-8:45 |
Poster talk: Maria Cristina Onorati (Palermo) Chromatin remodelers, nucleoplasm compartment and proteinopathies |
| 8:45-9:00 |
Poster talk: Graziano Martello (Padua) Cracking the naive Pluripotency code |
| 9:00-9:40 |
Irene Bozzoni (Rome) Regulatory circuitries controlled by long non coding RNAs |
| 9:40-10:20 |
Epigen Special Lecture Natalia Soshnikova (Mainz, Germany) Defining stem cell populations in the embryonic gut epithelium |
| 10:20-10:45 |
Coffee Break |
| 10:45-11:25 |
Stefano Biffo (Milan) Interactions between translational control and chromatin remodelling |
| 11:25-12:05 |
Gunter Meister (Regensburg, Germany) Regulation of microRNA biogenesis and function |
| 12:05-12:20 |
Poster talk: Ian Bonapace (Busto Arsizio) The epithelial to mesenchymal transition (EMT) induced by cancer associate fibroblasts in PC3 prostate cancer cells generates DNA hypo- and hyper-methylation in different sets of genes by regulating DNMTs and UHRF1 expression levels, which are reverted during mesenchymal to epithelial transition (MET) |
| 12:20-12:45 |
Sponsor talks |
| 12:45-14:00 |
Lunch Break |
| Session III |
Molecular biology for personalized medicine Chairs: Andrea Mattevi (Pavia), Caterina Missero (Naples) |
| 14:00-14:15 |
Poster talk: Alessandro Romanel (Trento) Tumor clone dynamics in lethal prostate cancer |
| 14:15-14:30 |
Poster talk: Christine Voellenkle (Milan) Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel non coding RNAs |
| 14:30-15:10 |
Francesca Ciccarelli (London, UK) Systems biology to identify novel anti-cancer therapeutic targets |
| 15:10-15:50 |
Giulio Superti-Furga (Vienna, Austria) OMICS and Drug Action |
| 15:50-17:15 |
Poster Session II (even numbers) & Coffee Break |
| 17:15-18:15 |
Science Policy Michele Garfinkel (EMBO) Policy options for conducting, reporting, and assessing science |
| 18:15-19:15 |
General SIBBM Society meeting |
| 19:30 |
"Notte al Muse" - Dinner and visit |
Friday, 13 June
| Session IV |
Molecular Medicine: towards therapy Chairs: Michela Denti, Anna Cereseto (Trento) |
| 9:00-9:15 |
Poster talk: Lorena Quirico (Turin) MiR-214 and miR-148b: a miRNA network controlling melanoma progression |
| 9:15-9:55 |
Mauro Giacca (Trieste) Steps towards cardiac muscle regeneration |
| 9:55-10:35 |
Fulvio Mavilio (Evry, France) Gene therapy of monogenic diseases |
| 10:35-10:50 |
Coffee Break |
| 10:50-11:30 |
Armenise Talk: Tiziana Bonaldi (Milan) Quantitative proteomics to investigate microRNAs: miR-17-92 counterbalances MYC and fine-tunes MYC-centered regulatory networks to sustain tumor growth |
| 11:30-11:45 |
Poster talk: Carla Esposito (Naples) Development of a combined strategy for selective targeting of glioma by aptamer-miRNA/antimiR chimeras |
| 11:45-12:00 |
Poster talk: Giulia Felician (Trieste) AAV6-mediated reactivation of Notch pathway after myocardial infarction fails to induce cardiac regeneration in adult mice |
| 12:00 |
Chiara D'Onofrio "Giovani" Award |
Posters
Posters with an odd number are presented during Poster Session I (Wednesday, 11 June). Posters with an even number are presented during Poster Session II (Thursday, 12 June).
The poster's maximum size is 85cm x 145cm (width x height).
P.1 Anita Annese (Bari) MiRNA profiling in Alzheimer’s disease by next-generation sequencing |
P.2 Laura Bavagnoli (Pavia) The different substrate specificities of human influenza virus PA, PA-X 61-codon and PA-X 41-codon endonucleases support distinct roles in the viral life cycle |
P.3 Federica Bertoletti (Pavia) Cross-talk of classic and alternative NHEJ repair of DNA breaks in cancer cells |
P.4 Francesca Bortolotti (Trieste) An in vivo selection strategy for the identification of novel cytokines inducing cardiac retention of mesenchymal stem cells after ischemic damage |
P.5 Laura Caberlotto (Rovereto) A systems biology investigation of neurodegenerative dementia reveals a pivotal role of autophagy |
P.6 Sonia Caccia (Segrate) Remittent C1-Inhibitor deficiency due to Arg378Cys mutation |
P.7 Antonio Casini (Mattarello (TN)) Identification of nucleoporins involved in HIV-1 integration site selection and provirus localization |
P.8 Morena Catillo (Pavia) Metabolic stress controls alternative splicing programs: relevance to cancer biology |
P.9 Emanuela Chiarella (Catanzaro) UMG-Lenti: novel dual-promoter lentiviral vectors that ensure efficient transgene- and reporter protein expression in human hematopoietic stem and progenitor cells |
P.10 Emanuela Chiarella (Catanzaro) Abundant expression of zinc finger protein 521 (ZNF521) in AMLs correlates with specific genetic aberrations and contributes to the leukaemic phenotype in AMLs with MLL rearrangements |
P.11 Lucia Cicchillitti (Rome) Identification of a novel NF-Y protein partner: characterization of NF-YA/LMNA nuclear complex |
P.12 Yari Ciribilli (Mattarello (TN)) Combined TNFα and Doxorubicin treatment of MCF7 cells uncovers cooperative interactions between p53 and NFκB resulting in enhanced cell plasticity |
P.13 Tiziana Coradin (Mattarello (TN)) Identification of UBC12 as a new cofactor of HIV-1 integrase |
P.14 Davide Corona (Palermo) Role of the Chromatin RemodelIing Factor ISWI in Tissue Regeneration |
P.15 Alice Cortesi (Milan) D4Z4 repeat regulates transcription mediating 3D interactions in the genome: biological and pathological implications |
P.16 Giuseppina Covello (Mattarello) Antisense RNA-induced exon-skipping for the gene therapy of Frontotemporal Dementia and Parkinsonism associated with chromosome 17 (FTPD-17) |
P.17 Annalisa Crudele (Rome) Role of LITAF during normal and neoplastic hepatocyte proliferation |
P.18 Vito D'Agostino (Mattarello (TN)) FK866 induces cap-dependent translation arrest via AMPK activation in leukemia cells |
P.19 Maria Chiara De Santis (Turin) Loss of PI3KC2α promotes tumorigenesis and aneuploidy in breast cancer |
P.20 Valerio Del Vescovo (Trento) mir-375 and mir-192 expression levels distinguish neuroendocrine from non-neuroendocrine tumors. Novel biomarkers from resected samples |
P.21 Emanuela Fanigliulo (Siena) The adaptor protein Rai: a novel player in multiple sclerosis pathogenesis |
P.22 Giulio Ferrero (Orbassano) Exploration of hormone-independent Estrogen Receptor α activity by integrative and comparative approaches |
P.23 Piera Ferro (Fisciano (SA)) Modulation of TFF1 expression in physiological and pathological conditions |
P.24 Stephen Findlay-Wilson (Trento) Development of a fluorescent imaging model for determining the cellular and viral factors influencing HIV-1 infectivity |
P.25 Francesca Fontana (Mattarello (TN)) Mechanisms of post-trascriptional regulation of gene expression in dementia |
P.26 Mattia Forneris (Turin) A functional strategy to characterize Quantitative Trait Loci |
P.27 Giacomo Frati (Milan) Patient-specific induced pluripotent stem cells (iPSCs) as a human-derived model to study metachromatic and globoid cell leukodystrophy |
P.28 Caterina Gabriele (Catanzaro) Prostate cancer biomarker discovery on tissue and serum samples by N-linked glycoprotein profiling and high resolution mass spectrometry |
P.29 Maria Nicola Gadaleta (Bari) Acetyl-L-carnitine chronic treatment to old rat increases biogenesis, turnover and antioxidant defenses in brain mitochondria whereas it reduces oxidized PRXs and the mtDNA4834 mutation content |
P.30 Angela Gallo (Rome) Oligophrenin-1 (OPHN1), a gene involved in X-Linked Intellectual Disability, undergoes RNA editing and alternative splicing during human brain development |
P.31 Sonia Iolanda Garritano (Mattarello (TN)) In-silico identification of enhancers bound by androgen receptor reveals allele dependent activity |
P.32 Martina Giannaccini (Pisa) Drug delivery to retinal pigmented epithelium via magnetic nanoparticles |
P.34 Francis Kobia (Milan) Pharmacologic inhibition of vacuolar H+ ATPase (V-ATPase) reduces physiologic and oncogenic Notch signaling |
P.35 Mario Lauria (Rovereto) Rank-based miRNA signatures as biomarkers for neuropsychiatric disorders |
P.36 Paola Lecca (Povo (TN)) A reverse engineering gene interaction method and application to prostate cancer molecular sub-classes |
P.37 Nadia Lobello (Catanzaro) Regulation of Stearoyl-CoA desaturase-1 (SCD1), a key factor for propagation and survival of lung cancer stem cells |
P.38 Pamela Lorenzi (Verona) RBM20 role in FHOD3 alternative splicing regulation |
P.39 Filippo Macchi (Busto Arsizio) The role of UHRF1 in CDH1 epigenetic regulation via promoter associated non-coding RNAs |
P.40 Monica Mancini (Busto Arsizio) Carcinogen–induced epigenetic switching in human retroelements: a mechanistic study on hydroquinone effects |
P.41 Laura Martini (Mattarello) In vitro evolution of new RNA sensors |
P.42 Michela Masè (Povo (TN)) Structural substrate of atrial fibrillation investigated by miRNAs profiling and histological assessment in cardiac surgery patients |
P.43 Valentina Miano (Colleretto Giacosa (TO)) Estrogen Receptor α regulated lncRNAs as new players in maintenance of breast cancer cells phenotype |
P.44 Enrico Moiso (Turin) Overexpression of the muscle specific chaperone Melusin delays heart failure and mortality in a mouse model of Emery Dreyfus cardiomyopathy |
P.45 Emanuele Monteleone (Turin) Potential role of Stat3 in controlling pluripotency and differentiation via lincRNAs transcriptional regulation |
P.46 Rosa Montone (Verona) SADDAN-FGFR3 signalling involves paxillin phosphorylation and causes cytoskeleton disorganization |
P.47 Nicoletta Nuzziello (Bari) sCLU as potential biomarker for the thyroid tumour |
P.48 Nadia Panera (Rome) Toll like receptor-(TLR) 4 and its downstream lipolysaccharide (LPS)-induced TNF-α factor (LITAF) during nonalcoholic fatty liver disease |
P.49 Ilaria Panzeri (Milan) LincRNAs landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4 |
P.50 Elvira Parrotta (Catanzaro) Understanding the role of mutated BRCA1 on cardiac homeostasis in human iPS-derived cardiomyocytes |
P.51 Marsha Pellegrino (Rome) MDM4/MDM2 association: a new potential therapeutic target for the activation of p53 oncosuppressive function |
P.52 Elisa Penna (Turin) MiR-214 promotes melanoma progression by controlling tumor-endothelial cell interactions during extravasation via ALCAM |
P.53 Gianluca Petris (Mattarello (TN)) Distinct requirements of VCP/p97 ATPase and YOD1 activities in ERAD |
P.54 Giulia Piaggio (Rome) In vivo molecular imaging during mammary tumor progression to identify new biomarkers useful for clinical applications |
P.55 Cristina Pirrone (Varese) Molecular detection of BCR-ABL1 genomic breakpoint for the molecular monitoring of residual diseased in chronic myeloid leukemia |
P.56 Marta Piscitelli (Milan) Spera-Experiment to Cure : reasons of research |
P.57 Cristina Potrich (Povo (TN)) OncomiR detection in extracellular fluids: a PDMS microdevice perspective |
P.58 Vittoria Raffa (Pisa) Magnetic nanoparticles can direct axonal growth |
P.59 Mauro Rassu (Sassari) Role of LRRK2 in the regulation of dopamine receptor trafficking |
P.60 Stefania Reineri (Colleretto Giacosa) Estrogen regulates neuroglobin transcription in neuronal and non-neuronal cancer cells |
P.61 Riccardo Ronzoni (Brescia) Aberrant disulphide interactions contribute to the secretory deficiency of Alpha 1-Antitrypsin mutants |
P.62 Annalisa Rossi (Trento) Functional characterization of Raly a new member of RNA-binding protein containing ribonucleoparticles family |
P.63 Maria Elisabetta Ruaro (Udine) Development of new tools to define prognosis and patient-tailored therapeutic strategies for low-grade glioma patients |
P.64 Stefania Scicchitano (Catanzaro) Critical role of zinc finger protein 521 in the regulation of growth and tumourigenic potential of human medulloblastoma cells |
P.65 Kavitha Siva (Trento) Could RNAi be a therapeutic approach for Fronto Temporal Dementia and Parkinsonism linked to chromosome 17? |
P.66 Letizia Straniero (Milan) Exploring the role of a ceRNA-based regulatory network, involving GBA and GBAP1, in Parkinson disease |
P.67 Alessandro Testori (Turin) Transcriptome evolution via transposable elements |
P.68 Mariaconcetta Varano (Catanzaro) Whole proteome and main Post-translational modifications (PTMs) analysis of K. pneumoniae clinical isolates |
P.69 Laura Vidalino (Trento) Dynamic association with the nucleoli of C14orf21, a novel PUF-containing RNA-binding protein in mammals |
P.70 Valeria Visone (Naples) A new analytical approach to study DNA protein interactions and modifications |
P.71 Germana Zaccagnini (San Donato Milanese, Milan) microRNA-210: a master miRNA of the hypoxia response |
P.72 Melania Zanchetta (Trieste) MID1/TRIM18 interacts with BRAF35 and regulates its ubiquitination |
P.73 Elisa Zucca (Pavia) Interplay of DNA polymerase λ, protection of telomeres (Pot) 1 and TERRA in telomere elongation |
P.74 Paola Zuccotti (Trento) Mapping HuD interactom by cross-linking and sequencing of hybrids |
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